Reviewing Bupropion for Depression: An Update with Dr. Derek Tracy

Derek Tracy
Dr. Derek Tracy

In this episode we interview Dr. Derek Tracy on the use of bupropion for depression.

Dr. Tracy is a Consultant Psychiatrist and the Associate Clinical Director for Crisis, Inpatient, and Rehabilitation services at Oxleas NHS Foundation Trust, London.

He is a BRC research fellow and the neuromodulation lead at the Institute of Psychiatry, Psychology, and Neuroscience, King’s College London. Dr. Tracy also sits on the Editorial Board of the British Journal of Psychiatry.

His team published a review paper in Therapeutics Advances in Psychopharmacology titled “Bupropion: a systematic review and meta-analysis of effectiveness as an antidepressant”.

We discuss the following topics:

  • The effectiveness of bupropion as monotherapy and combination therapy, and how it compares to other antidepressants
  • The limitations of the literature reviewed
  • The importance of considering the possibility of insomnia and agitation when prescribing this drug
  • Symptom domains for which bupropion may be more effective and symptoms for which it may be less effective
  • The use of bupropion to avoid and treat antidepressant-induced sexual dysfunction
  • Specific clinical situations in which this drug is a good therapeutic option