[Document] Use of Second-Generation Antipsychotics in Bipolar Disorder: A Practical Guide

By: Flavio Guzman, MD

This practical guide is an update on the use of second-generation antipsychotics (SGAs) for the treatment of bipolar disorder. It reviews uses in bipolar depression, mania and maintenance treatment.

The focus is on FDA-approved indications, off-label uses are not discussed in this guide.


  • Use in bipolar depression
  • Use in mania and mixed episodes
    • Intramuscular agents used for agitation
    • SGAs approved for use in children and adolescents
  • Use in maintenance treatment